Preparation of cetyl palmitate-based PEGylated solid lipid nanoparticles by microfluidic technique

In recent years, several studies have shown that the use of solid lipid nanoparticles (SLN) as a colloidal drug delivery system was more advantageous than emulsions, liposomes and polymeric nanoparticles. SLNs numerous advantages different nanosystems rule out many their drawbacks. Despite SLNs, translation from preclinical formulation to industrial scale-up is limited. order provide reproducible reliable method producing nanoparticles, thus, obtain an scale-up, methods synthesis by microfluidic been developed. Microfluidic technique allows good control continuous online compared in bulk, leading narrow size distribution, high batch-to-batch reproducibility, well feasibility. This work described optimization process produce microfluidics. The produced microfluidics were characterized complementary optical morphological techniques with those bulk method. loaded paclitaxel sorafenib, used model drugs. anti-cancer efficiency estimated 2D 3D tumour models two cell lines, cellular uptake also studied fluorescence-assisted measurements.